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Pasteurella multocida Vaccine Candidates: A Systematic Review
<p><em>Pasteurella multocida (P. multocida)</em> is the highly contagious causative agent of a broad range of diseases in animals as well as an occasional human pathogen. Economically significant infections caused by <em>P. multocida</em> include avian fowl cholera, rabbit snuffles, and hemorrhagic septicemia in cattle, goats and pigs. Chemotherapy of pasteurellosis infections has some limitations, such as high cost of treatment, low efficacy, and the possibility of therapy failure due to antibiotic resistance. Prophylactic immunization offers a safe and effective preventive measure in case of zoonotic diseases. Bacterins, live attenuated and some old traditional vaccines against pasteurellosis remain in use today, beside their limitations. However, the past few years have seen significant progress in research to identify modern, effective vaccine candidates, but there is no new vaccine produced by new strategies. While scientists should struggle with a lot of aspects to design vaccine producing strategies, this review shows how pasteurellosis vaccine evolved and the limitations in its application which need to be overcome. </p>
Pasteurella multocida, Pasteurellosis, Vaccines
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https://www.ajmb.org/En/Article.aspx?id=30423
https://www.ajmb.org/PDF/En/FullText/30423.pdf
SaiedMostaanDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran41578
AbbasGhasemzadehDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran41579
SoroushSardari54
Mohammad AliShokrgozarNational Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran202
GholamrezaNikbakht BrujeniDepartment of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran41580
MohsenAbolhassani41581
ParastooEhsaniDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran514
Mohammad RezaAsadi KaramDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran41582